Corticosteroids Therapy for COVID-19-Induced Hyposmia and Anosmia


Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran


USERN Office, Mazandaran University of Medical Sciences, Sari, Iran


Padmashree Institute of Management and Sciences, Bangalore, India


Department of Obstetrics, Maharshi Menhi Homoeopathic College and Hospital, Katihar, Bihar, India


Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Kingdom of Saudi Arabia


Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran


Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

B-ENT 2022; 18: 284-290
DOI: 10.5152/B-ENT.2022.21792
Read: 945 Downloads: 337 Published: 01 October 2022

Objective: Hyposmia and anosmia are the most frequent complaints of patients with COVID-19. It can disappear after a short time or can last for an unknown period. Finding a suitable treatment for restoring the patients’ smell. The objective of this study is to review the effects of numerous types of corticoids on COVID-19-induced hyposmia and anosmia.

Methods: A narrative literature review was performed to analyze the effects of different forms of corticosteroids in various dosages for the treatment of COVID-19-induced hyposmia and anosmia.

Results: There is not a lot of data on the effects of corticosteroids on COVID-19-induced hyposmia and anosmia; however, despite little evidence for the efficacy of these drugs in hyposmia and anosmia caused by COVID-19, their effect in improving these symptoms whether in oral or nasal spray forms has been reported in recent literature. Most of the studies show that corticosteroids, whether nasal or systemic, are not as effective as they are thought to be.

Conclusion: Using topical corticosteroids as nasal sprays or systemic corticosteroids cannot help to improve the patient’s ability to smell. These methods were sometimes mixed with other methods such as olfactory training to improve the patient’s olfactory sense. However, the results of the studies showed diversity in the efficacies of each treatment plan. In most of the studies which used olfactory training along with corticosteroid therapy as a therapy for hyposmia/anosmia induced by COVID-19, olfactory training showed a better result.

Cite this article as: Khazeei Tabari MA, Khandan M, Mirjalili R, et al. Corticosteroids therapy for COVID-19-induced hyposmia and anosmia. B-ENT. 2022;18(4):284-290.

EISSN 2684-4907