Embryology and epidemiology of cleft lip and palate


Department of Otorhinolaryngology, Head and Neck Surgery


Department of Maxillo-facial Surgery


Department of Plastic Surgery, The Cleft Lip and Palate Team, Hôpital Universitaire des Enfants Reine Fabiola, Brussels

B-ENT 2006; 2: Supplement 11-19
Read: 973 Downloads: 649 Published: 22 February 2020

Embryology and epidemiology of cleft lip and palate. Craniofacial anomalies, in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact. This article reviews the embryology of the face, lip, and palate to enhance the understanding of the pathogenesis of these lesions, with particular attention to the period of susceptibility during gestation, complexity, and the factors that may influence their development. It includes an overview of the prevalence and environmental and genetic causes of cleft lip – with or without cleft palate – and cleft palate.

EISSN 2684-4907