B-ENT
Original Articles

Evaluating the Effect of Multiple Passes to the Same Thyroid Nodule in the Fine-Needle Aspiration Biopsy Session on Obtaining Adequate or the Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance Cytological Result

1.

Division of Endocrinology and Metabolism, Ankara City Hospital, Ankara, Turkey

2.

Division of Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey

3.

Division of Biostatistics, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey

B-ENT 2024; 20: 112-120
DOI: 10.5152/B-ENT.2024.231357
Read: 456 Downloads: 317 Published: 21 March 2024

Background: To determine whether multiple fine-needle passes to the same thyroid nodule in the fine-needle aspiration (FNA) biopsy session affect sufficient and/or atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) cytological result.

Methods: Ultrasonography(US) and cyto-histopathology results of the nodules of patients were retrospectively analyzed. The nodules were divided into 2 groups according to the number of needle passes performed in the same FNA session as those with 1 pass (1-pass group) and those with 2 or 3 passes (multiple-pass group).

Results: Totally, 1409 (93.9%) nodules were performed 1 pass, and 91 (6.1%) were performed multiple pass(n=91).The rates of cystic/mixed nodule, macrocalcification, and Thyroid Imaging Reporting and Data System 3 score were higher in the multiple-pass group (P=.001, P=.039, P=.006, respectively). Adequacy and AUS/FLUS rates were similar between the 2 groups. When nodules with macrocalcifications and cystic/ mixed structures were evaluated as 2 separate subgroups, the rates of the adequacy and AUS/FLUS were similar between 1-pass and multiplepass groups within each subgroup.The number of passes showed no univariate or multivariate significant effect on sufficient and/or AUS/FLUS cytology results (P > .05).

Conclusion: Although more passes are performed in cystic/mixed and macrocalcified nodules estimating that the material would be insufficient with macroscopic on-site evaluation, needle insertion of 2 or 3 times does not affect obtaining sufficient and/or AUS/FLUS cytology compared to 1 pass.

Cite this article as: Dellal Kahramanca FD, Cuhaci Seyrek FN, Alkan A, Topaloglu O, Ersoy R, Cakir B. Evaluating the effect of multiple passes to the same thyroid nodule in the fine-needle aspiration biopsy session on obtaining adequate or the atypia of undetermined significance/follicular lesion of undetermined significance cytological result. B-ENT. 2024;20(2):112-120.

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