B-ENT
Original Article

Evaluation of olfactory bulb volume in patients with diabetic olfactopathy and comparison with healthy individuals

1.

Department of Radiology, University of Health Sciences, Prof. Dr. Cemil Taşçıoğlu City Hospital, İstanbul, Turkey

2.

Department of Otolaryngology, Head and Neck Surgery, School of Medicine, İstinye University, İstanbul, Turkey

3.

Department of Otolaryngology, Head and Neck Surgery, Medical Faculty, Cyprus International University, Lefkoşe, Cyprus

4.

Department of Otolaryngology, Avicenna Private Hospital, İstanbul, Turkey

B-ENT 2021; 17: 174-178
DOI: 10.5152/B-ENT.2021.21311
Read: 413 Downloads: 195 Published: 12 November 2021

Objective: Diabetic olfactopathy is defined as olfactory dysfunction in patients with diabetic neuropathy. In this study, we evaluated the olfactory bulb volume (OBV) using magnetic resonance imaging in patients with diabetic olfactopathy and compared the results with those of healthy individuals.

Methods: This study included 12 patients who were diagnosed with type 2 diabetes mellitus (T2DM) and were found to have diabetic olfactopathy using the Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test (Group 1); their OBV was evaluated using MRI. For comparison, 13 healthy individuals of a similar age, without any medical problems, were included as a control group (Group 2); their OBV and olfactory functions were also evaluated.

Results: Total CCCRC scores were 4.27 ± 0.67 in Group 1 and 6.42 ± 0.31 in Group 2; these scores significantly differed between the groups. The mean CCCRC scores in Groups 1 and 2 were moderately hyposmic and normosmic, respectively. The mean OBV values were 65.04 ± 6.97 mm3 and 76.46 ± 11.36 mm3 in Groups 1 and 2, respectively. Group 1 had significantly lower OBV values and CCCRC scores, compared with Group 2 (p < 0.01 for both groups).

Conclusion: The OBV was lower in patients with T2DM who developed diabetic olfactopathy than that in healthy individuals; the olfactory bulb was adversely affected by diabetes mellitus. This is the first study to demonstrate that the olfactory bulb is adversely affected by the presence of diabetic olfactopathy.

Cite this article as: Gürbüz D, Kesimli MC, Bilgili AM, Durmaz HÖ. Evaluation of olfactory bulb volume in patients with diabetic olfactopathy and comparison with healthy individuals. B-ENT 2021; 17(3): 174-8.

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