Original Article

Hypopharyngeal Cancer: Oncological Results After Primary Surgery


Department of Otorhinolaryngology, University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia


University Clinical Centre of Vojvodina, Clinic for Otorhinolaryngology and Head and Neck Surgery, Department of Laryngology, Oncology and Phoniatrics, Novi Sad, Serbia


Department of Otorhinolaryngology, Medical Faculty in Priština - Kosovska Mitrovica, Serbia


Department of Geriatrics, University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia


Oncology Institute of Vojvodina, Clinic for Internal Oncology, Sremska Kamenica, Serbia


Oncology Institute of Vojvodina, Clinic for Radiotherapy, Sremska Kamenica, Serbia

B-ENT 2022; 18: 176-183
DOI: 10.5152/B-ENT.2022.21814
Read: 593 Downloads: 268 Published: 01 July 2022

Objective: The main objective of this study was to analyze the oncological results and survival outcome in primarily surgically treated patients with hypopharyngeal cancer.

Methods: A total of 95 patients, who underwent primary open surgery for squamous cell carcinoma of the hypopharynx, were retrospectively reviewed during the period of 5 years following surgery. Overall and disease-free 5-year survival rates were measured, and potential prognostic factors influencing survival outcome were analyzed.

Results: Patients with hypopharyngeal carcinoma were usually diagnosed in advanced tumor-T stages: 73.7% as opposed to 26.3% in early T stages. Positive lymph node metastases (N+) were present in 80% of the patients. Overall 5-year survival rate was 44.2% and the 5-year disease-free survival was 41.7%. In the follow-up, a recurrence was observed in 36 (37.9%) patients, while 16 (16.8%) subjects developed a second primary tumor. The overall 5-year survival was significantly shortened in patients with N+ neck (39.5% opposed to 63.2% in N0; P=.047) and in those who developed a disease recurrence (25% opposed to 55.93% in those without recurrence; P=.022), especially those with locoregional neck lymph node and distant metastases (18.51% opposed to 54.41% in those without metastases; P=.001).

Conclusion: Hypopharyngeal cancer is usually presented in advanced stages. Primary surgical approach of these carcinomas enables satisfactory oncological results. The initial N+ neck, as well as the presence of disease relapse, especially neck and distant metastases, represents a negative prognostic factor of 5-year survival rate in patients with primarily surgically treated hypopharyngeal carcinoma.

Cite this article as: Jović RM, Dragičević D, Čanji K, et al. Hypopharyngeal cancer: Oncological results after primary surgery. B-ENT 2022;18(3):176-183.

EISSN 2684-4907