Original Article

Malignant tumors of the sinonasal tract in children


Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China

B-ENT 2021; 17: 234-238
DOI: 10.5152/B-ENT.2021.21559
Read: 668 Downloads: 324 Published: 20 December 2021

Objective: To investigate the clinical manifestations and diagnostic range of malignant masses presenting in the sinonasal tract of pediatric patients and describe the outcomes of endoscopic surgery (EES).

Methods: A retrospective cohort analysis was conducted at a special and tertiary university hospital. The study included patients from birth through 18 years of age with a diagnosis of malignant tumors in the sinonasal tract between 2006 and 2019. All the patients underwent endoscopic biopsy or surgery. The survival analysis was performed using Kaplan-Meier estimate and the comparison between groups with the log-rank test.

Results: A total of 55 patients were analyzed. Rhabdomyosarcoma, lymphoma, and solitary fibrous tumors were the 3 major diagnoses in these patients. The overall 5-year survival rate was 69.3%. The 5-year survival for each cancer type was 49.7% in rhabdomyosarcoma, 75.0% in lymphoma, and 83.2% in non-rhabdomyosarcoma solid tumors (p=0.018). Patients with a complete surgical resection had a higher 5-year survival rate (82.9%) than patients with an incomplete resection or biopsy (42.5%) (p=0.084).

Conclusion: Soft tissue sarcomas are expectedly more common in pediatric patients with sinonasal malignant tumors. EES for malignant sinonasal tumors is a safe and effective treatment for excision of these lesions.

Cite this article as: Liu Z, Feng X, Zhang H, et al. Malignant tumors of the sinonasal tract in children. B-ENT 2021; 17(4): 234-8.

EISSN 2684-4907