Cyclophosphamide, doxorubicin, and cisplatin in advanced salivary gland cancer
D. Debaere , V. Vander Poorten , S. Nuyts , E. Hauben , J. Schoenaers , P. Schöffski and P. M. J. Clement
Department of General Medical Oncology, Department of Otorhinolaryngology-Head and Neck Surgery, Department of Radiation Oncology, Department of Pathology, Leuven Cancer Institute, Department of Maxillofacial Surgery, University Hospitals Leuven, Catholic University Leuven, Belgium
Salivary glands; carcinoma; neoplasm metastasis; drug therapy; cisplatin
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Cyclophosphamide, doxorubicin, and cisplatin in advanced salivary gland cancer. Objectives: Advanced sali- vary gland cancer is a rare disease that comprises different histopathological tumour types; correspondingly, data on pal- liative systemic treatment are scarce. Combination chemotherapy with cyclophosphamide, doxorubicin, and cisplatin (CAP) has been reported to induce a reasonable response rate, although fewer than 100 cases have been described. We conducted a retrospective review of advanced salivary gland cancer patients treated with CAP. Methodology: Fifteen consecutive patients with recurrent, locally advanced, or metastatic progressive salivary gland can- cer treated with CAP were identified over a five-year period. The mean age at start of treatment was 53.5 years, and the male/female ratio was 11/4. The most common histological subtypes were adenoid cystic carcinoma and adenocarcino- ma not otherwise specified (NOS), with the parotid gland as the most frequently affected anatomical site. Results: A response rate of 60% was achieved, with one complete and eight partial responses and six stable diseases according to RECIST criteria. No patient progressed under treatment. An average of 5.4 treatment cycles were adminis- tered; median time to progression after ending CAP was 6.6 months, and median overall survival was 15.1 months. Patients with adenocarcinoma NOS appeared to benefit more than patients with adenoid cystic carcinoma, but had a shorter time to progression. Except for neutropenia with neutropenic fever and alopecia, no NCI-CTC grade III or IV toxicity was observed. Conclusion: This retrospective study confirms the clinically meaningful efficacy of CAP in advanced adenocarcinomas NOS of the salivary gland in routine practice, with acceptable safety levels.
Vol. 7, 2011, 1st trimester

Cyclophosphamide, doxorubicin, and cisplatin in advanced salivary gland cancer