Title:
Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients
Authors:
A. Baharudin , S. S. Moses ,M. Y. Musa , R. R. Ramli , C. S. Betz and N. Azman
Institutions:
Department of Otolaryngology - Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Penang; Department of Otorhinolaryngology, Klinikum der Universitaet Muenchen, Munich, Germany
Keywords:
Autofluorescence endoscopy; upper aerodigestive tract tumours; diagnosis
Pages:
111 - 118
Abstract:
Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients. Objectives: Autofluorescence is a highly sensitive, and specific, complementary diagnostic tool for the photodiagnosis of head and neck squamous cell carcinomas. Together with ease of use, these properties suggest that autofluorescence, used alongside white light endoscopy, could be a promising tool for the screening of high-risk populations. The aim of this study was to evaluate its effectiveness in detecting tumours involving the upper aerodigestive tract, in comparison with histopathologic examination. Methodology: A cross-sectional prospective study was carried out from June 2011 till March 2012. Forty-five patients with clinical evidence of suspicious lesions involving the upper aerodigestive tract were enrolled and examined using conventional white light, and autofluorescence endoscopy. A biopsy of each lesion was subsequently submitted for histopathologic examination. Results: Using histology as our gold standard, we compared the sensitivity, specificity, and predictive values of autofluorescenceendoscopyindetectingupperaerodigestivetracttumours.Incomparisontohistopathologicexamination, the sensitivity of autofluorescence endoscopy was 95%, with a specificity of 74% (P value<0.001). The positive and negative predictive values were 78%, and 94% respectively. These data confirm a statistically significant correlation between autofluorescence and histopathologic diagnoses. Conclusions: Autofluorescence endoscopy was effective in detecting upper aerodigestive tract tumours, with excellent discrimination between benign and malignant phenotypes; this methodology is an ideal adjunct to white light endoscopÔľ»y.
Issue:
Vol. 12, 2016, 2nd trimester


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Diagnosis of upper aerodigestive tract tumours using autofluorescence endoscopy in south east asian patients