Title:
Evaluation of the effects of oral isotretinoin on nasal function, taste,▯ and smell
Authors:
T.L. Kumral , D. Hancı , Ş. Güngör , A. Arslanoğlu , E. Özdemir , G. Yıldrım , Z. Saltürk , G. Berkiten , Y. Uyar
Institutions:
Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydani Training and Research Hospital, Istanbul, Turkey; Department of Dermatology, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
Keywords:
Isotretinoin, nasal function, olfaction, taste, mucociliary clearance
Pages:
185 - 190
Abstract:
Evaluation of the effects of oral isotretinoin on nasal function, taste, and smell. Objectives: Oral isotretinoin is commonly used to treat recalcitrant nodular acne. This study’s purpose is to explore the effects of oral isotretinoin on nasal patency, taste, and smell. Methodology: This study enrolled 39 patients who had acne vulgaris. Patients were treated with isotretinoinat a daily dose of 0.5-0.8 mg/kg body weight per day in divided doses over a 3-month period.All patients underwent both objective and subjective testing of nasal obstruction, olfaction, taste, and mucociliary clearance before treatment and at week 1 and month 3 of treatment. Results: We found that the nasal obstruction, taste and olfactory visual analog scores began to decrease even in the first week of drug treatment, and was even lower by month 3 (p<0.01). In the first week,the mucociliary clearance time also decreased and continued to fall at month 3 (p<0.01).It was revealed by the peak nasal inspiratory flow measurements that obstruction developed even during week 1 (p<0.01). Sinonasal outcome test scores significantly increased at the third-month results (p<0.01). Significant taste loss was evident by month 3 (p<0.05). However, although olfaction decreased somewhat by month 3, the fall was not significant. Conclusion:Isotretinoin triggers loss of nasal function, reducing the mucociliary clearance and taste sensations. Subjective deteriorations occurred earlier than the objective deteriorations.
Issue:
Vol. 14, 2018, 3rd trimester


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Evaluation of the effects of oral isotretinoin on nasal function, taste,▯ and smell