- Title:
- Induction chemotherapy before surgery for unresectable head and neck cancer
- Authors:
- H. Schmaltz , C. Borel , S. Ciftci , C. Takeda-Raguin , C. Debry , P. Schultz and A. Dupret-Bories
- Institutions:
- Department of Otorhinolaryngology, CHU Hautepierre, Strasbourg, France; Department of medical oncology, Centre Paul Strauss, France; Geriatric Department, Hôpital Universitaire de Strasbourg, Strasbourg, France; Department of Otorhinolaryngology, Institut Universitaire du Cancer, Toulouse, France
- Keywords:
- Head and neck cancer; induction chemotherapy; surgery; unresectable tumour
- Pages:
- 29 - 32
- Abstract:
- Induction chemotherapy before surgery for unresectable head and neck cancer. Objective: To preoperatively reduce tumour size in patients with locally advanced and/or non-resectable squamous cell carcinoma with induction chemotherapy in order to achieve surgical excision with clear margins and preserve quality of life. Methodology: In this study, 16 patients with locally advanced and/or non-resectable squamous cell carcinoma underwent induction chemotherapy with docetaxel, cisplatin, and 5-fluorouricil or paclitaxel, carboplatin, and cetuximab. Results: Over 80% of patients responded to induction chemotherapy. Histological examination of the 14 surgical specimens showed a total absence of residual cancer cells in 37.5% of cases. Conclusion: Concurrent radiation and chemotherapy is the standard treatment for locally advanced head and neck squamous cell carcinoma; however, induction chemotherapy may be beneficial in select patients.
- Issue:
- Vol. 12, 2016, 1st trimester
- Download:
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Induction chemotherapy before surgery for unresectable head and neck cancer