Title:
Induction chemotherapy before surgery for unresectable head and neck cancer
Authors:
H. Schmaltz , C. Borel , S. Ciftci , C. Takeda-Raguin , C. Debry , P. Schultz and A. Dupret-Bories
Institutions:
Department of Otorhinolaryngology, CHU Hautepierre, Strasbourg, France; Department of medical oncology, Centre Paul Strauss, France; Geriatric Department, Hôpital Universitaire de Strasbourg, Strasbourg, France; Department of Otorhinolaryngology, Institut Universitaire du Cancer, Toulouse, France
Keywords:
Head and neck cancer; induction chemotherapy; surgery; unresectable tumour
Pages:
29 - 32
Abstract:
Induction chemotherapy before surgery for unresectable head and neck cancer. Objective: To preoperatively reduce tumour size in patients with locally advanced and/or non-resectable squamous cell carcinoma with induction chemotherapy in order to achieve surgical excision with clear margins and preserve quality of life. Methodology: In this study, 16 patients with locally advanced and/or non-resectable squamous cell carcinoma underwent induction chemotherapy with docetaxel, cisplatin, and 5-fluorouricil or paclitaxel, carboplatin, and cetuximab. Results: Over 80% of patients responded to induction chemotherapy. Histological examination of the 14 surgical specimens showed a total absence of residual cancer cells in 37.5% of cases. Conclusion: Concurrent radiation and chemotherapy is the standard treatment for locally advanced head and neck squamous cell carcinoma; however, induction chemotherapy may be beneficial in select patients.
Issue:
Vol. 12, 2016, 1st trimester


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Induction chemotherapy before surgery for unresectable head and neck cancer