Title:
Nasopharingeal polymorphous low-grade adenocarcinoma in a patient with non- functioning pituitary macroadenoma
Authors:
M . Garzaro*, G. Pecorari*, V. Landolfo*, P. Campisi**, A. Reali*** and C. Giordano*
Institutions:
*I ENT Clinic, Physiopathology Department, **Department of biological sciences and human oncology, ***Radiotherapy Division, University of Turin, Turin, Italy
Keywords:
Polymorphous low-grade adenocarcinoma; nasopharynx; pituitary non-functioning adenoma; surgical therapy
Pages:
59 - 62
Abstract:
Nasopharingeal polymorphous low-grade adenocarcinoma in a patient with non-functioning pituitary macroadenoma. Background: Polymorphous low grade adenocarcinoma (PLGA) is a rare malignant neoplasm of the minor salivary glands occurring in the fifth and sixth decade with a 2:1 female predominance. The nasal cavity is involved in less than 1% of cases. The incidence of clinically recognisable pituitary adenoma is 15 cases/million/year. The prevalence of non-functioning pituitary adenoma (NFPA) is estimated to be 70-90 cases/million. Both types of adenoma represent 20-45% of pituitary tumours. Case report: The report describes the first case of PLGA associated with NFPA, both incidentally diagnosed. Three months after the exeresis of the NFPA using a trans-sphenoidal approach, an endoscopic resection of the PLGA was performed. No recurrence was observed during a 13 months follow-up. Conclusions: Complete surgical excision is the preferred management for PLGA. Radiotherapy has not been demon- strated to be effective in treating PLGA. The prognosis is good with a very low rate of metastasis and local recurrence.
Issue:
Vol. 6, 2010, 1st trimester


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Nasopharingeal polymorphous low-grade adenocarcinoma in a patient with non- functioning pituitary macroadenoma