Title:
Oncogenic osteomalacia induced by a sinonasal tumour: case report and review
Authors:
H. Kabtouri , R. Karmali , L. Spinato , M. Khamaktchian and P. Bisschop 1
Institutions:
1Department of ORL-Head and neck surgery, Université Libre de Bruxelles, Brugmann Hospital, Brussels, Belgium; 2Department of Internal Medicine, Université Libre de Bruxelles, Brugmann Hospital, Brussels, Belgium.
Keywords:
Oncogenic osteomalacia; paranasal sinuses; hypophosphatemia; fibroblast growth factor 23; phosphaturic mesenchymal tumour
Pages:
149 - 155
Abstract:
Oncogenic osteomalacia induced by a sinonasal tumour: case report and review. Background: Oncogenic osteomalacia (OOM) is a rare paraneoplastic syndrome characterized by hypophosphatemia and overexpression of a phosphaturic agent, fibroblast growth factor 23 (FGF23). OOM is associated with a variety of mesenchymal tumours referred to as phosphaturic mesenchymal tumours. Head and neck regions are concerned in 5-10% of cases. Methods and results: We report the case of a 42-year-old female with OOM caused by a hemangiopericytoma of the left ethmoid sinus. The period between first symptoms and surgical excision of the lesion was approximately 5 years. We also conducted a PubMed-based search to identify all cases of OOM related to sinonasal tumour. Twenty eight cases in the sinonasal area were reported in the literature. Conclusion: OOM is an important diagnosis because resection of the causative tumour results in cure of the disease.
Issue:
Vol. 10, 2014, 2nd trimester


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Oncogenic osteomalacia induced by a sinonasal tumour: case report and review