Title:
Platelet-Rich Fibrin (PRF): an autologous packing material for middle ear microsurgery
Authors:
P. Garin , Y. Peerbaccus , N. Mardyla , F. Mullier , D. Gheldof , Jean-Michel Dogne , L. Putz , J.P. Van Damme
Institutions:
1ENT Department, Mont-Godinne-Dinant University Hospital, Yvoir, Belgium; 2Anatomy Department, University of Namur, Namur, Belgium; Ste Elisabeth Hospital, Namur, Belgium; Hematology Laboratory, Namur Thrombosis and Hemostasis Center (NTHC), Nam5r Research Institutefor LIfe Sciences(NARILIS), Mont-Godinne Dinant University Hospital, Yvoir , Belgium; Department of Pharmacy, Namur Research Institute for LIfe Sciences (NARILIS), Namur Thrombosis and Hemostasis Center (NTHC),University of Namur, Namur, Belgium; 6Anaesthesiology Department, University hospital Mont-Godinne-Dinant, Yvoir, Belgium; ENT Department, Saint-Luc University Hospital, Brussels, Belgium
Keywords:
Chronic otitis media, cholesteatoma, otosclerosis, tympanoplasty
Pages:
27 - 34
Abstract:
Platelet-Rich Fibrin (PRF): an autologous packing material for middle ear microsurgery. Objectives: To assess the use of PRF prepared using an optimised protocol in middle ear surgery as a substitute for conventional pack- ing products of animal origin such as collagen derived from porcine skin. Methodology: A retrospective study of 108 patients in whom optimised PRF was used exclusively to pack the external auditory canal or middle ear. The effectiveness or harmlessness of the PRF was evaluated by assessing a range of parameters. A morphological comparison was also made of PRF produced using the Choukroun procedure and our procedure. Results: The success rate of the repair of the tympanic membrane one year after the surgery was 45/48 patients. In 5 of 63 patients in whom a retro-auricular approach and wall-up technique were used, granuloma was observed along the incision in the ear canal. Granuloma was not seen in any of the 23 patients undergoing a procedure with an endaural approach. Conclusion: The use of a material prepared from patients themselves and not of animal origin has numerous advantages in terms of biocompatibility and safety, without any adverse effect on the success rate for general middle ear procedures. The protocol is simple and does not prolong the time spent by the patient in the operating theatre. The Choukroun tech - nique. should be modified to prevent excessive failure rates in PRF processing.
Issue:
Vol. 10, 2014, 1st trimester


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Platelet-Rich Fibrin (PRF): an autologous packing material for middle ear microsurgery