Title:
Radiation-induced carcinosarcoma of the submandibular gland: case report and review of literature
Authors:
Y. M. Haidar and M. A. Rose
Institutions:
UC Irvine, Department of Otolaryngology – Head and Neck Surgery, Orange, CA; UC San Diego School of Medicine, Department of Radiation Oncology, La Jolla, CA
Keywords:
Radiation-induced malignancies; radiation-induced sarcomas; carcinosarcoma; head and neck cancer; intensity-modulated radiation therapy
Pages:
339 - 343
Abstract:
Radiation-induced carcinosarcoma of the submandibular gland: case report and review of literature. Radiation-induced carcinosarcoma (RICS) of the head and neck is a very rare and extremely aggressive entity. We present the case of a 60-year-old man diagnosed with a T2N2cM0 squamous cell carcinoma at the right base of the tongue (BOT). The patient was treated with neoadjuvant chemotherapy and 3D-conformal radiotherapy (3D-CRT) to the BOT and bilateral neck. He developed left submandibular firmness five years after treatment, initially diagnosed as radiation-induced fibrosis. The increasing size of the left submandibular mass two years later prompted further imaging, which showed a 2.2x1.8 cm mass in the left submandibular region in the previously irradiated field. This was diagnosed as a radiation-induced submandibular gland malignancy. This is the first reported case of a RICS in the submandibular gland and demonstrates the importance of early workup and evaluation of submandibular gland pathology in a patient with a history of radiation for a head and neck malignancy.
Issue:
Vol. 12, 2016, 4th trimester


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Radiation-induced carcinosarcoma of the submandibular gland: case report and review of literature