Title:
Salivary gland hypofunction in elderly patients with xerostomia
Authors:
J-S. Choi , I. Y. Hyun , J.-Y. Lim , Y.-M. Kim
Institutions:
Department of Otorhinolaryngology - Head and Neck Surgery, Inha University School of Medicine, Incheon, Republic of Korea; Department of Nuclear Medicine, Inha University School of Medicine, Incheon, Republic of Korea; Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Keywords:
Salivary gland; aging; xerostomia; salivary scintigraphy
Pages:
143 - 150
Abstract:
Salivary gland hypofunction in elderly patients with xerostomia. Problems/objectives : Xerostomia is usually related to salivary gland (SG) hypofunction and is a common complaint in elderly patients. This study was conducted to evaluate SG function in elderly patients with xerostomia and to determine whether the degree of xerostomia is correlated with SG dysfunction. Methodology: Thirty-two xerostomia patients aged over 65 years were enrolled in this study. Patients taking xerostomic drugs, those with a history of SG diseases or radiotherapy and those with any factor likely to affect SG function were excluded. Subjective symptoms were assessed using a self-reported questionnaire. SG function was quantified by determining salivary flow rates (SFR) and using scintigraphic parameters for the submandibular and parotid glands. Any correlations between the subjective symptoms and the objective findings were investigated. Twenty-four normal, healthy, young (mean age 29 years) subjects served as controls. Results: According to the xerostomia questionnaire, the symptomscores of the patients were significantly higher than those of the controls (p<0.001). Salivary flow testing showed that the patients’ unstimulated and stimulated flow rates were significantly lower than those of the controls (p = 0.005, p = 0.016, respectively). Regarding the scintigraphic parameters, the uptake ratio (UR) and maximum accumulation (MA) were smaller and the time interval from stimulation to minimum count (T) was grminer in patients. The unstimulated SFR and submandibular scintigraphic parameters were found to be significantly correlated with the degree of xerostomia. Conclusion: SFR and scintigraphic parameters may be helpful for thein the objective evaluation of xerostomia symptoms. The study also shows that unstimulated SFR and submandibular scintigraphic parameters reflect symptom severity in elderly xerostomia patients.
Issue:
Vol. 13, 2017, 2nd trimester


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Salivary gland hypofunction in elderly patients with xerostomia