Title:
Single, pauci, and multi-allergen immunotherapy
Authors:
C. Cingi , S.K. Wise , S.Y. Lin , N. Bayar Muluk , C.B. Franzese , M. Rudenko , E. Toskala , G.K. Scadding
Institutions:
Department of Otolaryngology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA; Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Otolaryngology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey; Department of Otolaryngology-Head & Neck Surgery, University of Missouri, Columbia, MO, USA; Department ofAllergy, LondonAllergy and Immunology, London, United Kingdom; Department of Otolaryngology-Head & Neck Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; RNTNE Hospital, University College Hospitals London, United Kingdom.
Keywords:
Allergen immunotherapy, allergens, sensitization, subcutaneous immunotherapy, sublingual immunotherapy, allergic rhinitis, allergic conjunctivitis, allergic asthma, polyallergy, polysensitization
Pages:
79 - 84
Abstract:
Single, pauci, and multi-allergen immunotherapy. Objectives: This paper’s aim is to review single, pauci, and multi-allergen immunotherapy. Methods: Search is made through PubMed, Google, Google Scholar and Proquest Central database of the Kırıkkale University Library. Results: Allergen immunotherapy (AIT) modifies the immune response to a specific allergen. AIT has been used to treat allergic rhinitis, allergic conjunctivitis, allergic asthma and also insect venom allergy. Immunotherapy can be administered subcutaneously (SCIT) or sublingually (SLIT). Patients may be mono-, pauci-, or polysensitized to allergens. Polysensitization is more common and usually increases with age.AIT is maximally effective when one or two allergens are used. There is a similar effect in both mono and polysensitized patients. However, in polysensitized patients, immunotherapy with multiple allergens is less effective compared with desensitization treatment in monosensitized patients using one allergen. This may relate to dose, or to the fact that polysensitization might merely reflect cross- reactivity to one or two major causative allergens. Conclusion: We suggest that in polyallergy, where symptoms of rhinitis or asthma, are related to the exposure of multiple allergens; would be a better subject for multiple allergen desensitizations than polysensitization. This need is to explore in well-designed experiments.
Issue:
Vol. 14, 2018, 2nd trimester


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Single, pauci, and multi-allergen immunotherapy