Title:
Touch imprint cytological diagnosis of nodal Langerhans Cell Histiocytosis
Authors:
D. Tamiolakis*, S. Barbagadaki*, E. Proimos**, S. Nikolaidou*, T. S. Chimona**, G. Georgiou*, G. Perogamvrakis** and C. E. Papadakis** *Department of Cytopathology, **Department of Ear-Nose-and Throat Surgery, General Hospital of Chania, Crete,
Institutions:
Greece
Keywords:
Langerhans cell histiocytosis; imprint cytology; lymph node
Pages:
115 - 118
Abstract:
Touch imprint cytological diagnosis of nodal Langerhans cell histiocytosis. Langerhans cell histiocytosis (LCH) is a rare neoplasm of the mononuclear phagocytic immunoregulatory system of unknown aetiology. Nodal involvement is uncommon. Cytological findings have seldom been described. A case study of LCH, arising in a sub- mandibular node of a 42-year-old female, is reported. Fine needle aspiration smears were highly cellular and composed of a mixed cell population including eosinophils, lymphocytes, neutrophils, and macrophages. Imprint slides from the surgical specimen of the excised node exhibited Langerhans cells with nuclear grooves, leading to a diagnosis suggestive of LCH. Immunohistochemical staining of the node sections with CD1a and S-100 confirmed this diagnosis. In conclu- sion,cytology may favorably contribute to the diagnosis of LCH.
Issue:
Vol. 5, 2009, 2nd trimester


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Touch imprint cytological diagnosis of nodal Langerhans Cell Histiocytosis