Title:
Transnasal endoscopic microfractured fat injection in glottic insufficiency
Authors:
A. M. Saibene, C. Pipolo, R. Lorusso, S. M. Portaleone and G. Felisati
Institutions:
Otolaryngology Department San Paolo Hospital, Department of Health Sciences, University of Milan, Milan, Italy
Keywords:
Glottic insufficiency; fat injection; fat augmentation; dysphonia; vocal fold medialisation
Pages:
229 - 234
Abstract:
Transnasal endoscopic microfractured fat injection in glottic insufficiency. Objective: We evaluated a novel treatment for glottic insufficiency involving the injection of autologous material with direct glottic visualisation in an  outpatient setting.  Methods: Three patients with vocal cord palsy underwent laryngoplasty under local anaesthesia using only a flexible  endoscope with a worki®g canal for Microfractured Fat Fibre-endoscopic Injection (MFFI). Adipose tissue was processed  using the Lipogems  device, which allows optimal purity, fluidity, and mesenchymal stem cell content in the resultant  emulsion.  Results: According to the preliminary data, MFFI was well tolerated and no complications were observed. During the  12-month follow-up period, voice improvement was constant in all three patients, hinting at the stem cell-related regenerative potential of the procedure.  Conclusions: MFFI was proven to be a useful and straightforward tool, combining all of the relevant advantages of other  known treatments for glottic insufficiency, and is an efficacious and innovative treatment that can be performed on an  outpatient basis using only autologous material.
Issue:
Vol. 11, 2015, 3rd trimester


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Transnasal endoscopic microfractured fat injection in glottic insufficiency