Title:
Wegener granulomatosis as possible cause of vertigo: case report and review
Authors:
J. Goderis , S. De Schepper , P. Vannieuwenhuyze and B. Schmelzer
Institutions:
ENT Department, UZ Ghent, De Pintelaan 185, 9000 Gent; ENT Department, ZNA Middelheim, Lindendreef 1, 2020 Antwerpen
Keywords:
Wegener Granulomatosis; Granulomatosis with Polyangiitis; Antibodies; Antineutrophil Cytoplasmic (ANCA); hearing loss; sensorineural; vertigo
Pages:
67 - 72
Abstract:
Wegener granulomatosis as possible cause of vertigo: case report and review. Objective: Wegener granulomatosis (WG) or granulomatosis with polyangiitis (GPA) is a multi-system necrotizing granulomatous vasculitis that classically affects the upper respiratory tract, lungs and kidneys. We report the unusual clinical course of a patient with WG, and we present a literature review on the association between WG and vertigo. Results: In our case, a 56-year-old female presented with a several-month history of chronic sinusitis and otalgia that was refractory to all initiated outpatient therapies. During hospitalization, a diagnostic evaluation revealed serious nasal crusting, chronic otitis media, and hematuria. Serologic testing showed elevated anti-neutrophil cytoplasmic antibodies (cĀ­ANCAs). The tentative diagnosis of Wegener granulomatosis was confirmed by renal biopsy. Upon admission, the patient developed an acute vertigo with nystagmus, nausea, and vomiting, accompanied by sensorineural hearing loss in one ear. Conclusions: Vestibular symptoms may be associated with Wegener granulomatosis.
Issue:
Vol. 11, 2015, 1st trimester


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Wegener granulomatosis as possible cause of vertigo: case report and review