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Abstract
Embryology and epidemiology of cleft lip and palate. Craniofacial anomalies, in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact. This article reviews the embryology of the face, lip, and palate to enhance the understanding of the pathogenesis of these lesions, with particular attention to the period of susceptibility during gestation, complexity, and the factors that may influence their development. It includes an overview of the prevalence and environmental and genetic causes of cleft lip – with or without cleft palate – and cleft palate.
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Article Info
Published In
Journal
B-ENT
Volume / Issue
Volume 2 · Issue Supplement 1
Pages
11-19
History
Published Online
April 15, 2006
Affiliations
N. Bernheim
Department of Otorhinolaryngology, HUDERF, Brussels; Centre Comprendre et Parler, Brussels, Belgium
M. Georges
Department of Otorhinolaryngology, Head and Neck Surgery
C. Malevez
Department of Maxillo-facial Surgery
A. De Mey
Department of Plastic Surgery, The Cleft Lip and Palate Team, Hôpital Universitaire des Enfants Reine Fabiola, Brussels
A. Mansbach
Department of Otorhinolaryngology, Head and Neck Surgery
Cite this Article
Bernheim, N., Georges, M., Malevez, C., Mey, A. D., & Mansbach, A. (2006). Embryology and epidemiology of cleft lip and palate. B-ENT, 2(Supplement 1), 11–19. Retrieved from https://www.b-ent.be/index.php/pub/article/view/60
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