Abstract
Induction chemotherapy before surgery for unresectable head and neck cancer. Objective: To preoperatively reduce tumour size in patients with locally advanced and/or non-resectable squamous cell carcinoma with induction chemotherapy in order to achieve surgical excision with clear margins and preserve quality of life.
Methodology: In this study, 16 patients with locally advanced and/or non-resectable squamous cell carcinoma underwent induction chemotherapy with docetaxel, cisplatin, and 5-fluorouricil or paclitaxel, carboplatin, and cetuximab.
Results: Over 80% of patients responded to induction chemotherapy. Histological examination of the 14 surgical specimens showed a total absence of residual cancer cells in 37.5% of cases.
Conclusion: Concurrent radiation and chemotherapy is the standard treatment for locally advanced head and neck squamous cell carcinoma; however, induction chemotherapy may be beneficial in select patients.
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Article Info
Published In
Journal
B-ENT
Volume / Issue
Volume 12 · Issue 1
Pages
29-32
History
Published Online
March 15, 2016
Affiliations
H. Schmaltz
Department of Otorhinolaryngology, CHU Hautepierre, Strasbourg, France
C. Borel
Department of medical oncology, Centre Paul Strauss, France
S. Ciftci
Department of Otorhinolaryngology, CHU Hautepierre, Strasbourg, France
C. Takeda-Raguin
Geriatric Department, Hôpital Universitaire de Strasbourg, Strasbourg, France
C. Debry
Department of Otorhinolaryngology, CHU Hautepierre, Strasbourg, France
P. Schultz
Department of Otorhinolaryngology, CHU Hautepierre, Strasbourg, France
A. Dupret-Bories
Department of Otorhinolaryngology, Institut Universitaire du Cancer, Toulouse, France
Cite this Article
Schmaltz, H., Borel, C., Ciftci, S., Takeda-Raguin, C., Debry, C., Schultz, P., & Dupret-Bories, A. (2016). Induction chemotherapy before surgery for unresectable head and neck cancer. B-ENT, 12(1), 29–32. Retrieved from https://www.b-ent.be/index.php/pub/article/view/616
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