B-ENT
Original Article

Are Antibiotics Sufficient for Treating Bacterial Rhinosinusitis? The Influence of Alpha-Lipoic Acid, a Potent Antioxidant, As an Additional Treatment in Bacterial Rhinosinusitis

1.

Department of Otorhinolaryngology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

2.

Department of Otorhinolaryngology, Atatürk University Faculty of Medicine, Erzurum, Turkey

3.

Department of Analytical Chemistry, Atatürk University Faculty of Pharmacy, Erzurum, Turkey

4.

Department of Pharmacology, Atatürk University Faculty of Medicine, Erzurum, Turkey

5.

Department of Biochemistry, Atatürk University Faculty of Pharmacy, Erzurum, Turkey

6.

Department of Pathology, Cumhuriyet University of Veterinary, Sivas, Turkey

7.

Department of Histlogy and Embryology, Atatürk University Faculty of Medicine, Erzurum, Turkey

8.

Department of Pathology, Atatürk University Faculty of Medicine, Erzurum, Turkey

B-ENT 2022; 18: 216-224
DOI: 10.5152/B-ENT.2022.21476
Read: 777 Downloads: 417 Published: 01 October 2022

Objective: Alpha-lipoic acid is an antioxidant agent with potential anti-inflammatory properties and is produced from octanoic acid. The aim of this study was to investigate the effects of alpha-lipoic acid on inflammation, oxidative status, tissue integrity in an animal model of experimen- tally induced acute rhinosinusitis and to compare these effects with the standard treatment, cefalosporin.

Methods: Totally 30 healthy Wistar Albino rats were used in the experiment. The animals were randomly divided into 6 groups. An experimental sinusitis model was created Staphylococcus Aureus (SA) in the groups except for the healthy group. Over a 10-day period, groups were treated daily either with 50 mg/kg cefazolin (SA+cefazolin), alpha-lipoic acid 100 mg/kg (SA+alpha-lipoic acid 100), alpha-lipoic acid 200 mg/kg (SA+alpha-lipoic acid 200), or alpha-lipoic acid 200 mg/kg+cefazolin 50 mg/kg (SA+alpha-lipoic acid 200+cefazolin). At the end of the test, the animals were euthanized, and the maxillary sinus mucosa was removed. Mucosa samples were examined for superoxide dismutase activity and glutathione, malondialdehyde, tumor necrosis factor-alpha mRNA, and interleukin-1β mRNA levels.

Results: Histopathological examination showed lesser changes in SA + cefazolin group compared to the control group and inflammation pro- portionally with alpha-lipoic acid dose in rhinosinusitis-induced groups treated with alpha-lipoic acid. Increased levels of malondialdehyde, tumor necrosis factor-alpha mRNA, and interleukin-1β mRNA in rhinosinusitis-induced groups approached the healthy group in SA+alpha- lipoic acid 200 + cefazolin group. Decreased superoxide dismutase activity and glutathione level in induced rhinosinusitis groups were close to that of healthy group in SA + alpha-lipoic acid 200 + cefazolin group.

Conclusion: The results of the study revealed that using a potent antioxidant and/or anti-inflammatory agent along with an antibacterial agent could be more effective in reducing oxidative stress and cytokine levels in the treatment of bacterial infections like sinusitis.

Cite this article as: Efe Atila N, Kaya Z, Atila A, et al. Are antibiotics sufficient for treating bacterial rhinosinusitis? The influence of alphalipoic acid, a potent antioxidant, as an additional treatment in bacterial rhinosinusitis. B-ENT. 2022;18(4):216-224.

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