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Venous malformations (VMs) are the most common low-flow vascular malformations in the head and neck region. They can occur anywhere in the head and neck region, and rarely even occur endolaryngeally. Magnetic resonance imaging is crucial in the diagnosis and evaluation of the extensiveness of VMs and remains the gold standard imaging modality. Thanks to next-generation sequencing, TEK, and PIK3CA mutations were recently identified as somatic mutations in VMs and may provide an opportunity to identify selected targeted therapies in addition to already existing modalities such as surgery and sclerotherapy. The mainstay of therapy for localized VMs remains surgery. In this case report, the excision of a PIK3CA mutated laryngeal venous malformation by TransOral Robotic Surgery is described.
Cite this article as: Eecke MV, Coppens DAG, Kenis C, et al. Excision of a PIK3CA mutated laryngeal venous malformation by TransOral robotic surgery (TORS). B-ENT. Published online September 2, 2025. doi: 10.5152/B-ENT.2025.241637